FOSREF provides specialized services for at-risk populations in its centers, as well as in the communities served by these centers known as LAKAY Centers.

FOSREF has established various centers/projects offering diagnosis and treatment services for STIs, prevention and care programs for violence against women and girls, HIV/AIDS prevention services including VCT and post-test club services, as well as care services for at-risk individuals who have tested HIV-positive. These include support group programs, psychosocial support, and assistance to affected families, as well as ARV treatment services for at-risk populations living with HIV.